Observational Comparative Effectiveness Research

An electronic practice-based network for observational comparative effectiveness research.

The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data from 8 organizations representing more than 500 clinicians and more than 400 000 patients. DARTNet was designed to increase knowledge of the comparative effectiveness of prescription medications and medical devices. Traditional observational comparative effectiveness research i...

Developing a Protocol for Observational Comparative Effectiveness Research

................................................................................................................................................ 7 Overview ............................................................................................................................................... 7 Identifying Decisions, Decisionmakers, Actions, and Context ......................................

CEPAC and comparative effectiveness research.

Methods in comparative effectiveness research.

Comparative effectiveness research (CER) seeks to assist consumers, clinicians, purchasers, and policy makers to make informed decisions to improve health care at both the individual and population levels. CER includes evidence generation and evidence synthesis. Randomized controlled trials are central to CER because of the lack of selection bias, with the recent development of adaptive and pra...

Introduction to Developing a Protocol for Observational Comparative Effectiveness Research: A User’s Guide

When making health care decisions, patients, health care providers, and policymakers routinely seek unbiased information about the effects of treatment on a variety of health outcomes. Nonetheless, it is estimated that more than half of medical treatments lack valid evidence of effectiveness,1-3 particularly for long-term and patient-centered outcomes. These outcomes include humanistic measures...